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Posts Tagged ‘dentistry research’

Friday, July 28th, 2017

Sydney Faculty of Dentistry lab’s 3D printing may revolutionise root canal therapy

Researchers have created 3D-printed artificial blood vessels that could revolutionize root canal therapy to help people retain fully functioning teeth.

Sydney Dental School

Learn more about Sydney Dental School

Professor Luiz Bardessono and his team published the breakthrough in Scientific Reports. He leads The Bertassoni Lab at Oregon Health and Science University and the Bioengineering Laboratory in the University of Sydney Faculty of Dentistry.

While current root canal therapy is effective in saving an infected or decayed tooth, the procedure may cause teeth to become brittle and susceptible to fracture over time.

Based on previous work fabricating artificial capillaries, the researchers placed a fibre mould made of sugar molecules across the root canal of extracted human teeth and injected a material similar to proteins found in the body filled with dental pulp cells.

The researchers removed the fiber to make a long microchannel in the root canal and inserted endothelial cells (cellls that are involved in filtering gases, fluid and molecules across cell membranes) isolated from the interior lining of blood vessels.

They then removed the fibre to make a long microchannel in the root canal and inserted endothelial cells isolated from the interior lining of blood vessels. After seven days, dentin-producing cells appeared near the tooth walls and artificial blood vessels formed inside the tooth.

Professor Bertassoni said the research proved artificial blood vessels can be used to treat root canals.

“This result proves that fabrication of artificial blood vessels can be a highly effective strategy for fully regenerating the function of the teeth.

“We believe that this finding may change the way that root canal treatments are done in the future,” said Professor Bertassoni.

Current root canal treatment involves removing infected dental tissues and replacing them with synthetic biomaterials covered by a protective crown, which often results in further decay over time.

“This process eliminates the tooth’s blood and nerve supply, rendering it lifeless and void of any biological response or defence mechanism.

“Without this functionality, adult teeth may be lost much sooner, which can result in much greater concerns, such as the need for dentures or dental implants,” he said.

Research at the Sydney Faculty of Dentistry

Sydney Dentistry’s multidisciplinary research approach brings together the complementary expertise of the university’s faculties, centres and institutes with that of their affiliated teaching hospitals, institutes and international research partnerships. Sydney dentistry researchers are not limited by the confines of the mouth, but enhance studies in fundamental cell biology, microbiology, molecular biology and biomechanics with their dental expertise—it is their goal to “put the mouth into health!”

Research areas

Dentistry research at the University of Sydney is structured around a number of cross-disciplinary themes that are focused on improving health outcomes. These themes encompass microbial pathogenicity, biomaterials, implant technology, cell biology, pathology, minimal intervention therapies for management of caries, education, and public health.

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Do you think studying at the University of Sydney Faculty of Dentistry is right for you? Please contact OzTREKK’s Australian Dental Schools Admissions Officer Caitlin Sargeant at caitlin@oztrekk.com for more information!

Wednesday, July 5th, 2017

Dentistry research at the front line of tobacco intervention

Dentistry research is at the front line of tobacco intervention

Sydney Dental School

Learn more about Sydney Dental School

Smoking is a primary risk factor for periodontal disease and oral cancer and is one of the leading preventable causes of death. Healthcare providers have access to evidence-based guidelines that can help patients quit smoking; however, the translation of that knowledge and adoption into daily practice remains low. Healthcare providers are missing opportunities to address tobacco-use with their patients due to limited time and lack of health behaviour change expertise.

Concerns around how best to manage patients’ tobacco-use are raised in dental settings across the world. Innovative strategies are emerging in the behavioural sciences area; however, screening, brief intervention, and referral to treatment (SBIRTs) methods can be difficult to apply to the individual patients.

How is dentistry research at the University of Sydney addressing this issue?

Professor Heiko Spallek, Pro-Dean of Dentistry at the University of Sydney  and Dr Brad Rindal, Associate Dental Director for Research at HealthPartners Institute, Minnesota are conducting a clinical trial to evaluate the effectiveness of Clinical Decision Support (CDS) to improve dental provider delivery of SBIRTs.

What does the clinical trial involve?

The overarching goal of this research is to reduce smoking-associated morbidity and mortality by increasing the number of dental patients who are referred for tobacco cessation counseling. This program aims to

  • evaluate the effectiveness of clinical decision support (CDS) and,
  • improve dental provider delivery of brief tobacco interventions and referrals to tobacco quitlines for further tobacco counseling.

In this research, the CDS is being integrated within two commonly used electronic dental record systems and will generate personalised evidence-based recommendations for dental providers. These records will help dental professionals to actively engage with patients who smoke as part of the course of usual dental care.

The tobacco CDS will be tested within two dental schools, the School of Dental Medicine at the University of Pittsburgh and the Indiana University School of Dentistry as well as sixteen private-practice clinics. The research project is funded by the National Institute of Dental and Craniofacial Research for over two million US dollars.

Sydney Dentistry’s Doctor of Dental Medicine

The Sydney Dental School’s DMD is a graduate-entry program that has been purposefully designed to adhere to the well-rounded course structure of the North American postgraduate model, but has also maintained the sophisticated clinical training for which the University of Sydney has come to be renowned, giving students an applicable knowledge of dental health from the community to the laboratory.

Program: Doctor of Medicine (MD)
Location: Sydney, New South Wales (Camperdown/Darlington campus)
Semester intake: February each year
Duration: 4 years

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Are you interested in dentistry at the University of Sydney ? Email OzTREKK’s Australian Dental Schools Admissions Officer Adam Smith at adam@oztrekk.com for more information!

Friday, May 13th, 2016

Research at Griffith School of Dentistry

Students of Griffith Dentistry have access to world-class facilities within the new $150 million purpose-built Griffith Health Centre on the Gold Coast Campus. These include a 96-chair dental clinic, commercial dental and clinical skills laboratories, high-level IT facilities, and research facilities. Along with teaching the dentists of the future, the Griffith School of Dentistry seeks to

  • enhance the quality, relevance and satisfaction of the educational experience for all our staff and students;
  • contribute to the development of a research culture across the university, and the professions in the wider practicing community;
  • become a recognised first port of call for industrial partners seeking research collaborations to advance health care and oral sciences.
Griffith School of Dentistry

Learn more about Griffith School of Dentistry

Five active Research Groups have been developed within the school:

The Dental Education Research Action Group

As the first new dental school in Australasia for 57 years the school regards it as a moral responsibility to be active in education research. The school has a unique opportunity to be avant garde in interprofessionalism (the major conceptual innovation of the School), in curriculum structure (a major opportunity provided by Griffith’s modular course structure across all disciplines), in pedagogy and evaluation. This research group has set as a first priority the creation of a comprehensive database of demography, psychosocial profile, knowledge attitudes and behaviour toward a range of health and social issues for all its student cohorts. This is an essential baseline against which to measure trends over time and the impact of their educational experiences.

The Centre of Excellence in Oral, Head, Neck and Thyroid Diseases

This is a major collaboration between the Griffith School of Dentistry and Oral Health, School of Medicine and Queensland Health Pathology Services. This aims to create the most modern and expert service, teaching and research centre in Australasia and the Pacific which has a high disease burden, especially of upper aero-digestive tract cancers.

The founding members of the Group have international reputations in the epidemiology, prevention, and pathology of these diseases. They are well connected to, and respected by, major relevant international scientific organisations, including the World Health Organisation. The members are regular contributors to the Head and Neck Oncology Multidisciplinary Team meetings at Princess Alexandra Hospital in collaboration with Professor William Coman and are developing laboratory collaborations with other QHPS laboratories, with UQ, QIMR, Mater Hospital and elsewhere at present. Activity ranges from the specialist consultancy service in oral medicine within the School of Dentistry and Oral Health, innovative diagnostic services, including telepathology to remote and off-shore locations, field epidemiology and prevention and laboratory research on diagnostic and prognostic markers, including modern molecular science.

The Osseointegrated Implant Research Group

The replacement of missing hard tissues in the human by or through metallic fixtures which are not only biocompatible but also integrate with bone, is a major surgical advance: whilst applicable to many parts of the body the science is led, globally, by dental implantology and often dental scientists. There is enormous commercial and professional activity which is tending to run ahead of the science. This highly expert group with skills ranging from cell and tissue biology, computing and engineering science, microbiology and surgical expertise and clinical trials and are already addressing questions of implant design in a collaboration between the School of Dentistry and Oral Health and the School of Engineering.

Public Health Research: The National Institute for Rural, Remote and Indigenous Oral Health

This research group has existing projects with local communities, with modest grant funding already, and the collaboration of Queensland Health, dealing with oral health promotion, and a joint PhD student between the School of Dentistry and Oral Health and Public Health at Griffith University on indigenous oral health needs and the barriers to care. A major proposal is being considered by industry for the creation of the NIRROH Australia wide. Discussions are in progress with the World Health Organisation, through the Western Pacific Regional Office, for World Health Organisation Collaborating Centre Status.

The Oral Microbiology and Immunology Group

Most oral and dental diseases have a strong component of microbial pathogenesis, with the host response essential to outcome. Furthermore the mouth is part of the body, the oral mucosa part of the whole mucosal immune system. Work has begun on extending understanding of the host response in periodontal infections, through identification of relevant microbial antigens in cases and controls; and on evaluating vaccines with potential to prevent oral fungal infections. This research group is establishing a clinical service to provide oral health care for the HIV positive community on the Gold Coast.

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Find out more about the Griffith School of Dentistry Contact OzTREKK’s Australian Dental Schools Admissions Officer Adam Smith at adam@oztrekk.com or 1-866-698-7355.